Michelin bosses are expected to sign a pledge by Christmas to deliver replacement jobs at its doomed Dundee site.
The French firm has agreed to play a role in redeveloping the site once its Baldovie factory closes by mid-2020.
Nicola Sturgeon told MSPs there is a shared aim to transform the area into a “key location for new economic employment”.
She said that could include industries such as recycling and low-carbon transport.
Speaking at First Minister’s Questions, Ms Sturgeon said: “Michelin will sign a memorandum of understanding with the Scottish Government to deliver on those commitments. We are looking to sign that before the end of this year.”
The firm announced in November that the tyre plant, which employs 845 workers, would cease production within 21 months.
The decision was blamed on falling demand for smaller tyres and cheaper imports from Asia.
A bid by the Michelin Action Group, which includes minsters, academics, union reps and factory management, to convince the firm to abandon its closure plans was not successful. But the memorandum of understanding leads to hopes a redeveloped site will produce new skilled jobs.
Responding to a question from Dundee East MSP Shona Robison, Ms Sturgeon said: “Derek Mackay (finance secretary) convened a very productive third meeting of the Michelin Dundee action group last Friday.
“Michelin will work in partnership with the Scottish Government, Scottish Enterprise, Dundee City Council and others to develop the next phase of the company’s presence in Scotland.
“Our shared aim now is to secure a long-term future for the site and to generate significant employment there.”
It was confirmed last week the factory would close when the MAG said it was pursuing transformation plans.
John Reid, factory manager at Michelin Dundee, said at the time: “Everyone involved in this partnership will work extremely hard to transform the Michelin site.
“In parallel with this work, Michelin will be supporting employees and doing everything we can to help them find the best outcomes possible.”