Oxford will check on Anthony Forde, Nathan Holland and Liam Kelly ahead of the visit of Southend.
Forde and Holland picked up minor hamstring injuries in Saturday’s 1-0 win at Ipswich and missed the midweek victory over Accrington.
Kelly has been building up his fitness for almost three weeks and could be in contention.
John Mousinho is still out but Mark Sykes came on as a substitute on Tuesday night despite struggling with illness in the build-up, so he should be involved again.
Sam Mantom is an injury doubt for second-bottom Southend.
The midfielder is carrying a knee problem and will be assessed on Friday.
Brandon Goodship and Jason Demetriou are fit and pushing to return to the starting line-up.
Stephen Humphrys, John White and Harry Lennon are still sidelined.