Her frantic mother, Margaret McIntosh, told the Tele today the family’s hearts were “shattered”.

She said, “We can’t think about anything else and we haven’t slept or eaten. Our minds are all over the place.”

Margaret issued a direct plea to her daughter. She said, “Mary, please come home — we are all devastated. We miss you very much and we love you. You’re breaking our hearts.”

Mary’s sister Lisa Hendry said it was “totally out of character” for her to not return home.

She said, “Mary wouldn’t even stay in the hospital overnight, she wanted to be home for her kids and her husband, that’s how she is.”

“She’s a devoted mother and wife and she’s looking forward to her daughter having a baby.”

Chief Inspector Suzie Mertes said the last confirmed sighting of Mary was at the King Street traffic lights near the entrance to the Wellgate car park at around 3am.

She said, “Just shortly before that we have footage of her crossing from Irving Square, but it doesn’t show which way she turned after that.

“CCTV and the sighting show she was in the company of a male wearing dark clothing and a jacket with white reflective piping on the back.”

CI Mertes said that police and her family were “increasingly concerned” at the disappearance.

She said, “At the moment we are treating this as a missing person inquiry and I am not going to speculate on anything more than that.”

A dedicated team of officers is investigating Mary’s disappearance although it is understood no specific areas of the city are being searched.

Another line of inquiry is a claim that a woman fitting Mary’s description was seen arguing with a man near the Medea factory in Dunsinane Industrial estate at around 4am on Thursday.

A missing person poster will be issued later today in an attempt to jog the memory of anyone who may have seen Mary after she left Fat Sams.

She was last seen wearing a black and white dress, black leggings, a white duffel coat and flat black shoes. She was also carrying a black handbag and an inflatable pink toy.

She is described as 5ft 2in and has long brown hair, blue eyes and walks with a limp.

Meanwhile, police have again appealed to the public for help in tracing a 16-year-old Dundee youth who has been missing for over a month.

Alec McDonald, described by police as a “vulnerable missing person” disappeared from his home in the city’s Thurso Crescent on January 27.

The last confirmed sighting of Alec was at around 11.30pm that night in Longforgan. However, police have a number of unconfirmed sightings of a youth matching his description in the Menzieshill and Charleston areas.

Anyone with information on either disappearance should contact Tayside Police immediately on 0300 111 2222 or contact any police officer.